The value of microparticles in detecting acute rejection episodes after liver transplantation.

Authors :: Morgul MH
Splith K
Leonhardt C
Raschzok N
Reutzel-Selke A
Schmuck RB
Andreou A
Atanasov G
Benzing C
Krenzien F
Hau HM
Felgendreff P
Klunk S
Pratschke J
Sauer IM
Schmelzle M
Source :: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2018 Feb; Vol. 23 (1), pp. 25-32. Date of Electronic Publication: 2017 Apr 03.
Publication Year :: 2018
Abstract: Context: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet.<br />Objective: We analyzed the correlation of plasma microparticle levels (MP) with AR.<br />Materials and Methods: MP (CD4, CD8, CD25, CD31, MHC) of 11 AR patients and 11 controls were analyzed within the first week after transplantation.<br />Results: CD4, CD8 and CD31 positive MP were higher in the AR, whereas overall MP count, CD25 and MHCI positive MP proportions did not differ between both groups.<br />Discussion and Conclusion: MP dynamics within the first period of transplantation could help to clarify on-going mechanisms of immunomodulation.

Subjects :: CD4 Antigens blood
CD8 Antigens blood
Female
Graft Rejection etiology
Humans
Liver Transplantation adverse effects
Male
Middle Aged
Platelet Endothelial Cell Adhesion Molecule-1 blood
Time Factors
Cell-Derived Microparticles metabolism
Graft Rejection blood
Graft Rejection diagnosis
Liver Transplantation methods

Language :: English
ISSN :: 1366-5804
Volume :: 23
Issue :: 1
Database :: MEDLINE
Journal :: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Publication Type :: Academic Journal
Accession number :: 28303731
Full Text :: https://doi.org/10.1080/1354750X.2017.1306754

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