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Neural tube closure and embryonic metabolism.
- Source :
-
Congenital anomalies [Congenit Anom (Kyoto)] 2017 Sep; Vol. 57 (5), pp. 134-137. Date of Electronic Publication: 2017 May 31. - Publication Year :
- 2017
-
Abstract
- Neural tube closure (NTC) is an embryonic process during formation of the mammalian central nervous system. Disruption of the dynamic, sequential events of NTC can cause neural tube defects (NTD) leading to spina bifida and anencephaly in the newborn. NTC is affected by inherent factors such as genetic mutation or if the mother is exposed to certain environmental factors such as intake of harmful chemicals, maternal infection, irradiation, malnutrition, and inadequate or excessive intake of specific nutrients. Although effects of these stress factors on NTC have been intensively studied, the metabolic state of a normally developing embryo remains unclear. State-of-the art mass spectrometry techniques have enabled detailed study of embryonic metabolite profiles and their distribution within tissues. This approach has demonstrated that glucose metabolism is altered during NTC stages involving chorioallantoic branching. An understanding of embryonic metabolic rewiring would help reveal the etiology of NTD caused by environmental factors.<br /> (© 2017 Japanese Teratology Society.)
- Subjects :
- Anencephaly etiology
Anencephaly pathology
Animals
Chorioallantoic Membrane metabolism
Chorioallantoic Membrane pathology
Embryo, Mammalian
Female
Humans
Infant, Newborn
Maternal Exposure adverse effects
Maternal-Fetal Exchange physiology
Metabolome
Neural Tube abnormalities
Neural Tube embryology
Pregnancy
Spinal Dysraphism etiology
Spinal Dysraphism pathology
Anencephaly metabolism
Energy Metabolism physiology
Glucose metabolism
Neural Tube metabolism
Spinal Dysraphism metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1741-4520
- Volume :
- 57
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Congenital anomalies
- Publication Type :
- Academic Journal
- Accession number :
- 28295633
- Full Text :
- https://doi.org/10.1111/cga.12219