Back to Search
Start Over
Cancer-Cell-Specific Mitochondria-Targeted Drug Delivery by Dual-Ligand-Functionalized Nanodiamonds Circumvent Drug Resistance.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2017 Apr 05; Vol. 9 (13), pp. 11780-11789. Date of Electronic Publication: 2017 Mar 21. - Publication Year :
- 2017
-
Abstract
- We demonstrate a nanotechnology approach for the development of cancer-cell-specific subcellular organelle-targeted drug nanocarriers based on photostable nanodiamonds (ND) functionalized with folic acid and mitochondrial localizing sequence (MLS) peptides. We showed that these multifunctional NDs not only distinguish between cancer cells and normal cells, and transport the loaded drugs across the plasma membrane of cancer cells, but also selectively deliver them to mitochondria and induce significant cytotoxicity and cell death compared with free Dox localized in lysosomes. Importantly, the cellular uptake of Dox was dramatically increased in a resistant model of MCF-7 cells, which contributed to the significant circumvention of P-glycoprotein-mediated drug resistance. Our work provides a novel method of designing nanodiamond-based carriers for targeted delivery and for circumventing drug resistance in doxorubicin-resistant human breast adenocarcinoma cancer cells.
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 9
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 28291330
- Full Text :
- https://doi.org/10.1021/acsami.6b15954