Development of new microsatellites for the hookworm Ancylostoma caninum and analysis of genetic diversity in Brazilian populations.

Authors :: Rabelo ÉML
Miranda RRC
Furtado LFV
Redondo RAF
Tennessen JA
Blouin MS
Source :: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2017 Jul; Vol. 51, pp. 24-27. Date of Electronic Publication: 2017 Mar 10.
Publication Year :: 2017
Abstract: Considering the great efforts towards formulating a vaccine against hookworms, and the concerns about the spread of drug resistance through hookworm populations, it is justified to study the molecular diversity and population genetic structure of these nematodes. This work had the aim to develop microsatellite markers to investigate the genetic structure and the molecular diversity of Brazilian populations of Ancylostoma caninum. Seven microsatellites markers were successfully used to characterize five Brazilian populations. These findings may contribute to a better comprehension of the ecology, patterns of transmission, drug resistances and development of immunotherapeutic strategies in hookworms.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)

Subjects :: Ancylostomiasis parasitology
Animals
Brazil
Databases, Genetic
Dogs
Genetics, Population
Heterozygote
Humans
Ancylostoma genetics
DNA, Helminth genetics
Genetic Loci
Genetic Variation
Microsatellite Repeats

Language :: English
ISSN :: 1567-7257
Volume :: 51
Database :: MEDLINE
Journal :: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Publication Type :: Academic Journal
Accession number :: 28288926
Full Text :: https://doi.org/10.1016/j.meegid.2017.03.008

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