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The effect of newer antiepileptic drugs in combination therapy.
- Source :
-
Epilepsy research [Epilepsy Res] 2017 May; Vol. 132, pp. 15-20. Date of Electronic Publication: 2017 Mar 02. - Publication Year :
- 2017
-
Abstract
- Purpose: To assess the impact of the new AEDs on overall outcome for patients with epilepsy.<br />Methods: In 2004, the effect of combination therapy on seizure frequency in adult patients with focal epilepsy was evaluated in a cross-sectional study in our center. We repeated this analysis ten years and eight new antiepileptic drugs (AED) later.<br />Results: In 2014, a higher percentage of patients with polytherapy (117 out of 396; 30%) were seizure-free compared with the original analysis (22%) (p=0.042). Eighty three out of 218 (38%) subjects on duo-therapy were seizure-free (27% in 2004) (p=0.040); in the 151 receiving triple therapy there were 30 (20%) seizure-free subjects (10% in 2004). Four out of 27 subjects (15%) with four AEDs were seizure-free (0% in 2004). The most common pairing of 52 different combinations for duo-therapy was levetiracetam-oxcarbazepine. Eighty different AEDs regimens were being used in the patients administered three AEDs.<br />Conclusion: Our combined data from these two studies indicate that some patients with focal epilepsy might benefit from newer AEDs as an adjunctive therapy in the hope they could acquire seizure freedom.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Aged
Carbamazepine therapeutic use
Cross-Sectional Studies
Drug Therapy, Combination methods
Female
Humans
Levetiracetam
Male
Middle Aged
Oxcarbazepine
Piracetam therapeutic use
Retrospective Studies
Seizures drug therapy
Treatment Outcome
Anticonvulsants therapeutic use
Carbamazepine analogs & derivatives
Epilepsy drug therapy
Piracetam analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6844
- Volume :
- 132
- Database :
- MEDLINE
- Journal :
- Epilepsy research
- Publication Type :
- Academic Journal
- Accession number :
- 28282542
- Full Text :
- https://doi.org/10.1016/j.eplepsyres.2017.02.020