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Genomic heterogeneity of Salmonella enterica serovar Typhimurium bacteriuria from chronic infection.
- Source :
-
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2017 Jul; Vol. 51, pp. 17-20. Date of Electronic Publication: 2017 Mar 07. - Publication Year :
- 2017
-
Abstract
- We sequenced the genomes of 14 sequential Salmonella enterica serovar Typhimurium isolates obtained over a five year period from a patient with persistent Salmonella bacteriuria. The isolates formed five distinct lineages; two of which co-existed over four years. We inferred that the observed within-patient variation resulted from mutation events.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Anti-Bacterial Agents therapeutic use
Bacteriuria drug therapy
Bacteriuria pathology
Chronic Disease
High-Throughput Nucleotide Sequencing
Humans
Male
Microbial Sensitivity Tests
Mutation Rate
Phylogeny
Salmonella Infections drug therapy
Salmonella Infections pathology
Salmonella typhimurium classification
Salmonella typhimurium drug effects
Salmonella typhimurium isolation & purification
Serogroup
Bacteriuria microbiology
DNA, Bacterial genetics
Genes, Bacterial
Polymorphism, Single Nucleotide
Salmonella Infections microbiology
Salmonella typhimurium genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1567-7257
- Volume :
- 51
- Database :
- MEDLINE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 28279807
- Full Text :
- https://doi.org/10.1016/j.meegid.2017.03.004