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Cortisol: a potent biphasic modulator at GABAA-receptor complexes in the guinea pig isolated ileum.
- Source :
-
Neuroscience letters [Neurosci Lett] 1987 Nov 10; Vol. 82 (1), pp. 101-6. - Publication Year :
- 1987
-
Abstract
- Cortisol had a biphasic action on GABAA-receptor-mediated contractile responses, enhancing at picomolar concentrations (1-10 pM) and inhibiting at higher concentrations (10-1000 nM). There was a sinistral shift of the GABA dose-response curve in the presence of 10 pM cortisol, with a significant potentiation of the GABA-induced contractions over the lower dose range of GABA (3-30 microM), whereas 100 nM cortisol caused a non-parallel dextral shift of the GABA dose-response curve, with a depression of the maximum GABA response indicative of non-competitive antagonism. Cortisol at various concentrations did not affect GABAB-receptor-mediated ileal relaxations, or the baclofen-induced depression of twitch contractions to transmural stimulation. Such concentrations of cortisol also did not affect ileal responses to exogenously applied acetylcholine or cholinergic twitch contractions themselves. These results suggest that cortisol is a specific, and very potent modulator at GABAA-receptor complexes in the guinea pig ileum.
- Subjects :
- Animals
Baclofen pharmacology
Female
Guinea Pigs
Ileum drug effects
In Vitro Techniques
Male
Receptors, GABA-A drug effects
Taurine analogs & derivatives
Taurine pharmacology
gamma-Aminobutyric Acid pharmacology
Hydrocortisone pharmacology
Ileum metabolism
Muscle Contraction drug effects
Receptors, GABA-A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 82
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 2827068
- Full Text :
- https://doi.org/10.1016/0304-3940(87)90178-9