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Relationship between radioprotective and neuromotor effects of S-2(3-aminopropyl-amino)ethylphosphorothioate (WR-2721) in mice.
- Source :
-
Neurotoxicology and teratology [Neurotoxicol Teratol] 1987 Sep-Oct; Vol. 9 (5), pp. 333-7. - Publication Year :
- 1987
-
Abstract
- The radioprotective and neuromotor effects of WR-2721 were studied in male albino ICR strain mice. The protective activity was evaluated by graded doses of WR-2721 (50-400 mg/kg, IP) against whole body 60Co gamma irradiation at a single maximal lethal threshold dose rad (i.e., 1250 rad). The neuromotor effects of the drug were assayed by its action, at the same dose range as used in the protection assay, on spontaneous motor activity (SMA) and wire hanging performance (WHP). Drug doses were administered 30 min before radiation exposure and neurobehavioral testings. The results showed a dose-dependent increase in radioprotection and an inhibition in the neuromotor tasks. The radioprotective efficacy was seen at doses at which intrinsic neuromotor deficits were detected (100-400 mg/kg). A dose-related parallelism of protective efficacy and neurobehavioral toxicity (i.e., SMA inhibition and WHP disruption) was also observed. The present findings suggest that WR-2721 induces neuromotor dysfunctions along with its radioprotectivity.
- Subjects :
- Amifostine administration & dosage
Amifostine pharmacology
Animals
Behavior, Animal drug effects
Dose-Response Relationship, Drug
Male
Mice
Mice, Inbred ICR
Motor Activity drug effects
Radiation-Protective Agents
Amifostine toxicity
Neuromuscular Junction drug effects
Organothiophosphorus Compounds toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0892-0362
- Volume :
- 9
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neurotoxicology and teratology
- Publication Type :
- Academic Journal
- Accession number :
- 2826981
- Full Text :
- https://doi.org/10.1016/0892-0362(87)90027-4