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Risk factors for incident asthma and COPD in a cohort of young adults.
- Source :
-
The clinical respiratory journal [Clin Respir J] 2018 Mar; Vol. 12 (3), pp. 1021-1029. Date of Electronic Publication: 2017 Mar 29. - Publication Year :
- 2018
-
Abstract
- Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study.<br />Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014.<br />Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV <subscript>1</subscript> <100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV <subscript>1</subscript> <100% predicted (all male cases had FEV <subscript>1</subscript> <100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34).<br />Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.<br /> (© 2017 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Asthma diagnosis
Asthma physiopathology
Comorbidity trends
Denmark epidemiology
Female
Follow-Up Studies
Forced Expiratory Volume
Humans
Incidence
Male
Pulmonary Disease, Chronic Obstructive diagnosis
Pulmonary Disease, Chronic Obstructive physiopathology
Risk Factors
Sex Factors
Skin Tests
Spirometry
Time Factors
Vital Capacity
Young Adult
Asthma epidemiology
Population Surveillance methods
Pulmonary Disease, Chronic Obstructive epidemiology
Risk Assessment
Subjects
Details
- Language :
- English
- ISSN :
- 1752-699X
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The clinical respiratory journal
- Publication Type :
- Academic Journal
- Accession number :
- 28268257
- Full Text :
- https://doi.org/10.1111/crj.12622