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Factors associated with an inadequate hypoglycemia in the insulin tolerance test in Japanese patients with suspected or proven hypopituitarism.
- Source :
-
Endocrine journal [Endocr J] 2017 Apr 29; Vol. 64 (4), pp. 387-392. Date of Electronic Publication: 2017 Mar 03. - Publication Year :
- 2017
-
Abstract
- We attempted to identify the predictors of an inadequate hypoglycemia in insulin tolerance test (ITT), defined as a blood glucose level higher than 2.8 mmol/L after insulin injection, in Japanese patients with suspected or proven hypopituitarism. A total of 78 patients who had undergone ITT were divided into adequate and inadequate hypoglycemia groups. The relationships between the subjects' clinical parameters and inadequate hypoglycemia in ITT were analyzed. Stepwise logistic regression analysis identified high systolic blood pressure (SBP) and high homeostasis model assessment of insulin resistance (HOMA-IR) as being independent factors associated with inadequate hypoglycemia in ITT. Receiver operating characteristic (ROC) curve analysis revealed the cutoff value for inadequate hypoglycemia was 109 mmHg for SBP and 1.4 for HOMA-IR. The areas under ROC curve for SBP and HOMA-IR were 0.72 and 0.86, respectively. We confirmed that high values of SBP and HOMA-IR were associated with inadequate hypoglycemia in ITT, regardless of the degree of reduction of pituitary hormone levels. Furthermore, the strongest predictor of inadequate hypoglycemia was obtained by using the cutoff value of HOMA-IR. Our results suggest that HOMA-IR is a useful pre-screening tool for ITT in these populations.
- Subjects :
- Adult
Asian People
Blood Glucose analysis
Blood Pressure
Female
Humans
Hypoglycemia diagnosis
Hypoglycemia metabolism
Hypoglycemia physiopathology
Hypopituitarism diagnosis
Hypopituitarism metabolism
Hypopituitarism physiopathology
Insulin
Japan
Male
Middle Aged
Retrospective Studies
Risk Factors
Diagnostic Techniques, Endocrine
Hypoglycemia etiology
Hypopituitarism complications
Insulin Resistance
Subjects
Details
- Language :
- English
- ISSN :
- 1348-4540
- Volume :
- 64
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Endocrine journal
- Publication Type :
- Academic Journal
- Accession number :
- 28260701
- Full Text :
- https://doi.org/10.1507/endocrj.EJ16-0332