Back to Search
Start Over
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1987 Nov; Vol. 84 (22), pp. 8120-4. - Publication Year :
- 1987
-
Abstract
- Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that modifies glycosylation by inhibiting alpha-glucosidase I. Castanospermine is shown to inhibit syncytium formation induced by the envelope glycoprotein of the human immunodeficiency virus and to inhibit viral replication. The decrease in syncytium formation in the presence of castanospermine can be attributed to inhibition of processing of the envelope precursor protein gp160, with resultant decreased cell surface expression of the mature envelope glycoprotein gp120. In addition, castanospermine may cause defects in steps involved in membrane fusion after binding of CD4 antigen. The antiviral effects of castanospermine may be due to modifications of the envelope glycoprotein that affect the ability of the virus to enter cells after attachment to the CD4 cell receptor.
- Subjects :
- Animals
Antigens, Differentiation, T-Lymphocyte metabolism
Cell Line
Cricetinae
Cricetulus
Female
Fibroblasts
HIV physiology
HIV Envelope Protein gp120
Humans
Lymphocytes physiology
Ovary
Protein Precursors metabolism
Protein Processing, Post-Translational drug effects
Receptors, Virus metabolism
Retroviridae Proteins physiology
Tumor Cells, Cultured
Alkaloids pharmacology
Cell Fusion drug effects
Glycoside Hydrolase Inhibitors
HIV drug effects
Indolizines
Retroviridae Proteins biosynthesis
Virus Replication drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 84
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 2825177
- Full Text :
- https://doi.org/10.1073/pnas.84.22.8120