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Neuroprotective Caffeoylquinic Acid Derivatives from the Flowers of Chrysanthemum morifolium.
- Source :
-
Journal of natural products [J Nat Prod] 2017 Apr 28; Vol. 80 (4), pp. 1028-1033. Date of Electronic Publication: 2017 Mar 01. - Publication Year :
- 2017
-
Abstract
- Three new caffeoylquinic acid derivatives, chrysanthemorimic acids A-C (1-3), and 11 known compounds (4-14) were isolated and characterized from the flowers of Chrysanthemum morifolium. Their structures were confirmed by spectroscopic data as well as by comparison of the experimental and calculated electronic circular dichroism spectra. Chrysanthemorimic acids A-C possess a rare 8-oxa-bicyclo[3.2.1]oct-3-en-2-one ring that is formed through a [5+2] cycloaddition of caffeoylquinic acid with a d-glucose derivative. Compounds 1-3, 6-8, 12, and 13 displayed significant effects against hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells at 10 μM.
- Subjects :
- Chlorogenic Acid analogs & derivatives
Chlorogenic Acid chemistry
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal chemistry
Flavonoids chemistry
Glucose analysis
Hydrogen Peroxide analysis
Molecular Structure
Neuroprotective Agents chemistry
Nuclear Magnetic Resonance, Biomolecular
Chlorogenic Acid isolation & purification
Chlorogenic Acid pharmacology
Chrysanthemum chemistry
Drugs, Chinese Herbal isolation & purification
Drugs, Chinese Herbal pharmacology
Flowers chemistry
Neuroprotective Agents isolation & purification
Neuroprotective Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 80
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 28248102
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.6b01026