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Modular Activating Receptors in Innate and Adaptive Immunity.
- Source :
-
Biochemistry [Biochemistry] 2017 Mar 14; Vol. 56 (10), pp. 1383-1402. Date of Electronic Publication: 2017 Mar 01. - Publication Year :
- 2017
-
Abstract
- Triggering of cell-mediated immunity is largely dependent on the recognition of foreign or abnormal molecules by a myriad of cell surface-bound receptors. Many activating immune receptors do not possess any intrinsic signaling capacity but instead form noncovalent complexes with one or more dimeric signaling modules that communicate with a common set of kinases to initiate intracellular information-transfer pathways. This modular architecture, where the ligand binding and signaling functions are detached from one another, is a common theme that is widely employed throughout the innate and adaptive arms of immune systems. The evolutionary advantages of this highly adaptable platform for molecular recognition are visible in the variety of ligand-receptor interactions that can be linked to common signaling pathways, the diversification of receptor modules in response to pathogen challenges, and the amplification of cellular responses through incorporation of multiple signaling motifs. Here we provide an overview of the major classes of modular activating immune receptors and outline the current state of knowledge regarding how these receptors assemble, recognize their ligands, and ultimately trigger intracellular signal transduction pathways that activate immune cell effector functions.
- Subjects :
- Amino Acid Sequence
Animals
Antigens genetics
Antigens immunology
Gene Expression Regulation
Humans
Killer Cells, Natural cytology
Killer Cells, Natural immunology
Ligands
Lymphocyte Subsets cytology
Lymphocyte Subsets immunology
Models, Molecular
Myeloid Cells cytology
Myeloid Cells immunology
Protein Conformation
Receptors, Immunologic genetics
Receptors, Immunologic metabolism
Adaptive Immunity
Antigens chemistry
Immunity, Innate
Receptors, Immunologic chemistry
Signal Transduction immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-4995
- Volume :
- 56
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28248088
- Full Text :
- https://doi.org/10.1021/acs.biochem.6b01291