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Serum neutralizing antibody titers in dairy cattle administered an inactivated vesicular stomatitis virus vaccine.

Serum neutralizing antibody titers in dairy cattle administered an inactivated vesicular stomatitis virus vaccine.

Authors :
Gearhart MA
Webb PA
Knight AP
Salman MD
Smith JA
Erickson GA
Source :
Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 1987 Oct 01; Vol. 191 (7), pp. 819-22.
Publication Year :
1987

Abstract

Two doses of a formalin-killed, cell culture-derived vesicular stomatitis virus (vsv)-New Jersey serotype vaccine were administered intramuscularly, 30 days apart, to all lactating and nonlactating cows in a 350-cow dairy herd. Serum specimens were obtained serially from 96 cows before vaccination and at 30, 52 and 80 days after vaccination and from 24 of these cows 175 days after vaccination. Serum neutralizing antibody titers to vsv-New Jersey serotype were determined from serum-dilution, plaque-reduction tests. Serum neutralizing antibody titers also were determined during the same period for 67 nonvaccinated heifers in the herd. Peak group geometric mean serum neutralizing antibody titers of 1:530.46 +/- 1.14 (group geometric mean titer log10, 2.725 +/- 0.055) developed 21 days after the second vaccination, but decreased to a low value of 1:65.36 +/- 1.38 (group geometric mean titer log10, 1.815 +/- 0.142) by 175 days after vaccination. The nonvaccinated group had no detectable antibody titer to vsv-New Jersey serotype throughout the study. All serum specimens from the vaccinates and controls were negative for heterologous reactivity to vsv-Indiana serotype.

Details

Language :
English
ISSN :
0003-1488
Volume :
191
Issue :
7
Database :
MEDLINE
Journal :
Journal of the American Veterinary Medical Association
Publication Type :
Academic Journal
Accession number :
2824413