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Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration.
- Source :
-
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2017; Vol. 2017, pp. 9548767. Date of Electronic Publication: 2017 Jan 24. - Publication Year :
- 2017
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Abstract
- Purpose. To compare serum levels of malondialdehyde (MDA) in patients with wet age-related macular degeneration (wAMD), patients with dry AMD (dAMD), and patients without AMD and to evaluate the efficacy of nutritional supplementation for treating elevated serum MDA in patients with wAMD. Methods. MDA levels were measured in sera from 20 patients with wAMD, 20 with dAMD, and 24 without AMD. Patients with wAMD were randomized to receive or not receive nutritional supplementation (10 patients in each group), and MDA levels were measured after 3 months of treatment. Results. MDA levels in patients with wAMD were significantly greater compared with patients without AMD. In eyes with wAMD, there was a significant correlation between MDA levels and choroidal neovascularization lesion area. Serum MDA levels decreased in most patients that received supplementation and significantly increased in those who did not. Conclusion. Baseline serum MDA levels were elevated in patients with wAMD, and MDA levels were directly correlated with choroidal neovascularization lesion area. In addition, nutritional supplementation appeared to exert a protective effect against oxidative stress in patients with wAMD.<br />Competing Interests: The authors declare that there is no conflict of interests regarding the publication of this paper.
- Subjects :
- Aged
Choroidal Neovascularization blood
Choroidal Neovascularization pathology
Female
Humans
Macular Degeneration blood
Macular Degeneration pathology
Male
Wet Macular Degeneration blood
Wet Macular Degeneration pathology
Choroidal Neovascularization diet therapy
Dietary Supplements
Macular Degeneration diet therapy
Malondialdehyde blood
Wet Macular Degeneration diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0994
- Volume :
- 2017
- Database :
- MEDLINE
- Journal :
- Oxidative medicine and cellular longevity
- Publication Type :
- Academic Journal
- Accession number :
- 28243361
- Full Text :
- https://doi.org/10.1155/2017/9548767