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Multiple sclerosis: an example of pathogenic viral interaction?
- Source :
-
Virology journal [Virol J] 2017 Feb 28; Vol. 14 (1), pp. 42. Date of Electronic Publication: 2017 Feb 28. - Publication Year :
- 2017
-
Abstract
- A hypothesis is formulated on viral interaction between HHV-6A and EBV as a pathogenic mechanism in Multiple Sclerosis (MS). Evidence of molecular and genetic mechanisms suggests a link between HHV-6A infection and EBV activation in the brain of MS patients leading to intrathecal B-cell transformation. Consequent T-cell immune response against the EBV-infected cells is postulated as a pathogenic basis for inflammatory lesion formation in the brain of susceptible individuals. A further link between HHV-6A and EBV involves their induction of expression of the human endogenous retrovirus HERV-K18-encoded superantigen. Such virally induced T-cell responses might secondarily also lead to local autoimmune phenomena. Finally, research recommendations are formulated for substantiating the hypothesis on several levels: epidemiologically, genetically, and viral expression in the brain.
Details
- Language :
- English
- ISSN :
- 1743-422X
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Virology journal
- Publication Type :
- Academic Journal
- Accession number :
- 28241767
- Full Text :
- https://doi.org/10.1186/s12985-017-0719-3