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Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy.

Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy.

Authors :
Xu X
Wu J
Liu Y
Saw PE
Tao W
Yu M
Zope H
Si M
Victorious A
Rasmussen J
Ayyash D
Farokhzad OC
Shi J
Source :
ACS nano [ACS Nano] 2017 Mar 28; Vol. 11 (3), pp. 2618-2627. Date of Electronic Publication: 2017 Mar 03.
Publication Year :
2017

Abstract

With the capability of specific silencing of target gene expression, RNA interference (RNAi) technology is emerging as a promising therapeutic modality for the treatment of cancer and other diseases. One key challenge for the clinical applications of RNAi is the safe and effective delivery of RNAi agents such as small interfering RNA (siRNA) to a particular nonliver diseased tissue (e.g., tumor) and cell type with sufficient cytosolic transport. In this work, we proposed a multifunctional envelope-type nanoparticle (NP) platform for prostate cancer (PCa)-specific in vivo siRNA delivery. A library of oligoarginine-functionalized and sharp pH-responsive polymers was synthesized and used for self-assembly with siRNA into NPs with the features of long blood circulation and pH-triggered oligoarginine-mediated endosomal membrane penetration. By further modification with ACUPA, a small molecular ligand specifically recognizing prostate-specific membrane antigen (PSMA) receptor, this envelope-type nanoplatform with multifunctional properties can efficiently target PSMA-expressing PCa cells and silence target gene expression. Systemic delivery of the siRNA NPs can efficiently silence the expression of prohibitin 1 (PHB1), which is upregulated in PCa and other cancers, and significantly inhibit PCa tumor growth. These results suggest that this multifunctional envelope-type nanoplatform could become an effective tool for PCa-specific therapy.

Details

Language :
English
ISSN :
1936-086X
Volume :
11
Issue :
3
Database :
MEDLINE
Journal :
ACS nano
Publication Type :
Academic Journal
Accession number :
28240870
Full Text :
https://doi.org/10.1021/acsnano.6b07195