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Antibiotic treatment at delivery shapes the initial oral microbiome in neonates.
- Source :
-
Scientific reports [Sci Rep] 2017 Feb 27; Vol. 7, pp. 43481. Date of Electronic Publication: 2017 Feb 27. - Publication Year :
- 2017
-
Abstract
- Oral microorganisms are important determinants of health and disease. The source of the initial neonatal microbiome and the factors dictating initial human oral microbiota development are unknown. This study aimed to investigate this in placental, oral and gut microbiome profiles from 36 overweight or obese mother-baby dyads as determined by 16S rRNA sequencing. Expression of five antibiotic resistance genes of the β-lactamase class was analysed in the infant oral microbiota samples by QPCR. The neonatal oral microbiota was 65.35% of maternal oral, 3.09% of placental, 31.56% of unknown and 0% of maternal gut origin. Two distinct neonatal oral microbiota profiles were observed: one strongly resembling the maternal oral microbiota and one with less similarity. Maternal exposure to intrapartum antibiotics explained the segregation of the profiles. Families belonging to Proteobacteria were abundant after antibiotics exposure while the families Streptococcaceae, Gemellaceae and Lactobacillales dominated in unexposed neonates. 26% of exposed neonates expressed the Vim-1 antibiotic resistance gene. These findings indicate that maternal intrapartum antibiotic treatment is a key regulator of the initial neonatal oral microbiome.
- Subjects :
- Bacillales classification
Bacillales genetics
Bacillales isolation & purification
Cohort Studies
Female
Humans
Infant, Newborn
Lactobacillales classification
Lactobacillales genetics
Lactobacillales isolation & purification
Maternal Exposure
Microbiota genetics
Obesity microbiology
Parturition physiology
Pregnancy
Proteobacteria classification
Proteobacteria genetics
Proteobacteria isolation & purification
RNA, Ribosomal, 16S genetics
Streptococcaceae classification
Streptococcaceae genetics
Streptococcaceae isolation & purification
beta-Lactamases genetics
beta-Lactamases isolation & purification
Anti-Bacterial Agents therapeutic use
Mouth microbiology
Obesity drug therapy
Placenta microbiology
beta-Lactam Resistance genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28240736
- Full Text :
- https://doi.org/10.1038/srep43481