NPY 1 Receptors Participate in the Regulation of Myocardial Contractility in Rats.

Authors :: Masliuko PM
Anikina TA
Zverev AA
Krylova AV
Moiseev KY
Zefirov TL
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Feb; Vol. 162 (4), pp. 418-420. Date of Electronic Publication: 2017 Feb 27.
Publication Year :: 2017
Abstract: Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10 <superscript>-7</superscript> M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP-3226 reduced the force of myocardial contractions. Pretreatment of myocardial strips with this blocker abolished the positive inotropic effect of Leu(31)Pro(34)NPY, which attested to important role of NPY <subscript>1</subscript> receptors in myocardial contraction.

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