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Seronegative myasthenia gravis associated with malignant thymoma.
- Source :
-
Neuromuscular disorders : NMD [Neuromuscul Disord] 2017 May; Vol. 27 (5), pp. 417-418. Date of Electronic Publication: 2017 Feb 02. - Publication Year :
- 2017
-
Abstract
- Myasthenia gravis (MG) is generally caused by antibodies directed against the neuromuscular junction, including antibodies against the postsynaptic nicotinic acetylcholine receptor (AChR). Pathologic abnormalities of the thymus gland, including thymoma, are associated with MG. We report a 56-year-old woman who presented with double vision. Single fiber EMG confirmed myasthenia gravis. AChR, striational muscle and MuSK antibodies were absent in the serum. Chest CT demonstrated a malignant thymoma. We report the first case of seronegative myasthenia gravis associated with malignant thymoma. The case challenges the conventional wisdom that all patients with thymoma associated MG test positive for antibodies against AChR.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Diagnosis, Differential
Female
Humans
Middle Aged
Myasthenia Gravis blood
Myasthenia Gravis diagnostic imaging
Myasthenia Gravis drug therapy
Thymoma blood
Thymoma diagnostic imaging
Thymoma therapy
Thymus Neoplasms blood
Thymus Neoplasms diagnostic imaging
Thymus Neoplasms therapy
Myasthenia Gravis complications
Thymoma complications
Thymus Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2364
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuromuscular disorders : NMD
- Publication Type :
- Academic Journal
- Accession number :
- 28238572
- Full Text :
- https://doi.org/10.1016/j.nmd.2017.01.023