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Electrochemical [ 11 C]CO 2 to [ 11 C]CO conversion for PET imaging.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Mar 07; Vol. 53 (20), pp. 2982-2985. - Publication Year :
- 2017
-
Abstract
- The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([ <superscript>11</superscript> C]CO) from cyclotron-produced carbon-11 carbon dioxide ([ <superscript>11</superscript> C]CO <subscript>2</subscript> ) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [ <superscript>11</superscript> C]CO from [ <superscript>11</superscript> C]CO <subscript>2</subscript> . Produced [ <superscript>11</superscript> C]CO was subsequently converted to [ <superscript>11</superscript> C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 53
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 28234400
- Full Text :
- https://doi.org/10.1039/c7cc00319f