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Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity.
- Source :
-
Immunity [Immunity] 2017 Feb 21; Vol. 46 (2), pp. 301-314. - Publication Year :
- 2017
-
Abstract
- Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infections in infants and is characterized by pulmonary infiltration of B cells in fatal cases. We analyzed the B cell compartment in human newborns and identified a population of neonatal regulatory B lymphocytes (nBreg cells) that produced interleukin 10 (IL-10) in response to RSV infection. The polyreactive B cell receptor of nBreg cells interacted with RSV protein F and induced upregulation of chemokine receptor CX3CR1. CX3CR1 interacted with RSV glycoprotein G, leading to nBreg cell infection and IL-10 production that dampened T helper 1 (Th1) cytokine production. In the respiratory tract of neonates with severe RSV-induced acute bronchiolitis, RSV-infected nBreg cell frequencies correlated with increased viral load and decreased blood memory Th1 cell frequencies. Thus, the frequency of nBreg cells is predictive of the severity of acute bronchiolitis disease and nBreg cell activity may constitute an early-life host response that favors microbial pathogenesis.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- B-Lymphocytes, Regulatory virology
Bronchiolitis, Viral pathology
CD4-Positive T-Lymphocytes immunology
CX3C Chemokine Receptor 1
Enzyme-Linked Immunosorbent Assay
Enzyme-Linked Immunospot Assay
Gene Expression Profiling
Humans
Infant, Newborn
Lymphocyte Activation immunology
Oligonucleotide Array Sequence Analysis
Respiratory Syncytial Virus Infections pathology
Respiratory Syncytial Viruses
Transcriptome
B-Lymphocytes, Regulatory immunology
Bronchiolitis, Viral immunology
Receptors, Chemokine immunology
Respiratory Syncytial Virus Infections immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4180
- Volume :
- 46
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 28228284
- Full Text :
- https://doi.org/10.1016/j.immuni.2017.01.010