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A Diastereoselective Multicomponent Reaction for Construction of Alkynylamide-Substituted α,β-Diamino Acid Derivatives To Hunt Hits.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2017 Mar 17; Vol. 82 (6), pp. 2862-2869. Date of Electronic Publication: 2017 Mar 06. - Publication Year :
- 2017
-
Abstract
- A highly diasetereoselective Mannich-type multicomponent reaction was developed to rapidly construct alkynylamide-substituted α,β-diamino acid derivatives from simple starting materials under mild conditions in moderate to good yields for hit hunting. Most of the resulting products 4 exhibited good anticancer activity in HCT116, BEL7402, and SMMC7721 cells.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 82
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28225272
- Full Text :
- https://doi.org/10.1021/acs.joc.6b02761