Back to Search
Start Over
Unusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne.
- Source :
-
Scientific reports [Sci Rep] 2017 Feb 22; Vol. 7, pp. 43138. Date of Electronic Publication: 2017 Feb 22. - Publication Year :
- 2017
-
Abstract
- Hipposponlachnins A (1) and B (2), possessing an unprecedented tetracyclo [9.3.0.0 <superscript>2,8</superscript> .0 <superscript>3,7</superscript> ] tetradecane ring system, and the probable biogenetic precursor [3, (1R*,2E,4R*,7E,10S*,11S*,12R*)-10, 18-diacetoxydolabella-2,7-dien-6-one] of 1‒2 were isolated from the South China Sea marine sponge Hippospongia lachne. The structures of the novel compounds were determined using integrated spectroscopic methods in combination with single-crystal X-ray diffraction analysis. Compounds 1‒2 showed potent inhibitory activity on the release of β-hexosaminidase, a biomarker for degranulation, as well as the production of pro-inflammatory cytokine IL-4 and lipid mediator LTB <subscript>4</subscript> in DNP-IgE-stimulated RBL-2H3 cells.
- Subjects :
- Animals
Anti-Allergic Agents chemistry
Anti-Allergic Agents isolation & purification
Cell Line
Cell Survival drug effects
China
Crystallography, X-Ray
Diterpenes chemistry
Diterpenes isolation & purification
Molecular Structure
Rats
Seawater
Spectrum Analysis
Anti-Allergic Agents pharmacology
Aquatic Organisms chemistry
Diterpenes pharmacology
Porifera chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 28224981
- Full Text :
- https://doi.org/10.1038/srep43138