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Antimicrobial Use for and Resistance of Zoonotic Bacteria Recovered from Nonhuman Primates.
- Source :
-
Comparative medicine [Comp Med] 2017 Feb 01; Vol. 67 (1), pp. 79-86. - Publication Year :
- 2017
-
Abstract
- As a growing threat to human and animal health, antimicrobial resistance (AMR) has become a central public-health topic. Largescale surveillance systems, such as the National Antimicrobial Resistance Monitoring System (NARMS), are now established to monitor and provide guidance regarding AMR, but comprehensive literature on AMR among NHP is sparse. This study provides data regarding current antimicrobial use strategies and the prevalence of AMR in zoonotic bacteria recovered from NHP within biomedical research institutions. We focused on 4 enteric bacteria: Shigella flexneri, Yersinia enterocolitica, Y. pseudotuberculosis, and Campylobacter jejuni. Fifteen veterinarians, 7 biomedical research institutions, and 4 diagnostic laboratories participated, providing susceptibility test results from January 2012 through April 2015. Veterinarians primarily treated cases caused by S. flexneri, Y. enterocolitica, and Y. pseudotuberculosis with enrofloxacin but treated C. jejuni cases with azithromycin and tylosin. All isolates were susceptible to the associated primary antimicrobial but often showed resistance to others. Specifically, S. flexneri isolates frequently were resistant to erythromycin (87.5%), doxycycline (73.7%), and tetracycline (38.3%); Y. enterocolitica isolates to ampicillin (100%) and cefazolin (93.6%); and C. jejuni isolates to methicillin (99.5%) and cephalothin (97.5%). None of the 58 Y. pseudotuber-culosis isolates was resistant to any tested antimicrobial. Notably, resistance patterns were not shared between this study's NHP isolates and human isolates presented by NARMS. Our findings indicate that zoonotic bacteria from NHP diagnostic samples are broadly susceptible to the antimicrobials used to treat the clinical infections. These results can help veterinarians ensure effective antimicrobial therapy and protect staff by minimizing occupational risk.
- Subjects :
- Animals
Campylobacter Infections drug therapy
Campylobacter Infections epidemiology
Campylobacter jejuni isolation & purification
Cross-Sectional Studies
Enterobacteriaceae Infections drug therapy
Enterobacteriaceae Infections epidemiology
Microbial Sensitivity Tests statistics & numerical data
Microbial Sensitivity Tests veterinary
Prevalence
Primate Diseases
Primates
Retrospective Studies
Shigella flexneri isolation & purification
Surveys and Questionnaires
Yersinia enterocolitica isolation & purification
Yersinia pseudotuberculosis isolation & purification
Zoonoses drug therapy
Zoonoses microbiology
Anti-Bacterial Agents therapeutic use
Campylobacter Infections veterinary
Campylobacter jejuni drug effects
Drug Resistance, Microbial
Enterobacteriaceae Infections veterinary
Shigella flexneri drug effects
Yersinia enterocolitica drug effects
Yersinia pseudotuberculosis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2769-819X
- Volume :
- 67
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Comparative medicine
- Publication Type :
- Academic Journal
- Accession number :
- 28222842