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Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? A meta-analysis.
- Source :
-
Critical care (London, England) [Crit Care] 2017 Feb 22; Vol. 21 (1), pp. 36. Date of Electronic Publication: 2017 Feb 22. - Publication Year :
- 2017
-
Abstract
- Background: The effects of body mass index (BMI) on the prognosis of acute respiratory distress syndrome (ARDS) are controversial. We aimed to further determine the relationship between BMI and the acute outcomes of patients with ARDS.<br />Methods: We searched the Pubmed, Embase, Medline, Cochrane Central Register of Controlled Trials (CENTRAL), and ISI Web of Science for trials published between 1946 and July 2016, using "BMI" or "body mass index" or "overweight" or "obese" and "ARDS" or "ALI" or "acute respiratory distress syndrome" or "acute lung injury", without limitations on publication type or language. Heterogeneity and sensitivity analyses were conducted, and a random-effects model was applied to calculate the odds ratio (OR) or mean difference (MD). Review Manager (RevMan) was used to test the hypothesis using the Mann-Whitney U test. The primary outcome was unadjusted mortality, and secondary outcomes included mechanical ventilation (MV)-free days and length of stay (LOS) in the intensive care unit (ICU) and in hospital.<br />Results: Five trials with a total of 6268 patients were pooled in our final analysis. There was statistical heterogeneity between normal-weight and overweight patients in LOS in the ICU (I <superscript>2</superscript> = 71%, χ <superscript>2</superscript> = 10.27, P = 0.02) and in MV-free days (I <superscript>2</superscript> = 89%, χ <superscript>2</superscript> = 18.45, P < 0.0001). Compared with normal weight, being underweight was associated with higher mortality (OR 1.59, 95% confidence interval (CI) 1.22, 2.08, P = 0.0006), while obesity and morbid obesity were more likely to result in lower mortality (OR 0.68, 95% CI 0.57, 0.80, P < 0.00001; OR 0.72, 95% CI 0.56, 0.93, P = 0.01). MV-free days were much longer in patients with morbid obesity (MD 2.64, 95% CI 0.60, 4.67, P = 0.01), but ICU and hospital LOS were not influenced by BMI. An important limitation of our analysis is the lack of adjustment for age, sex, illness severity, comorbid illness, and interaction of outcome parameters.<br />Conclusions: Obesity and morbid obesity are associated with lower mortality in patients with ARDS.
- Subjects :
- Acute Lung Injury mortality
Humans
Intensive Care Units organization & administration
Intensive Care Units statistics & numerical data
Length of Stay trends
Obesity complications
Obesity mortality
Overweight complications
Overweight mortality
Respiratory Distress Syndrome mortality
Statistics, Nonparametric
Acute Lung Injury complications
Body Mass Index
Patient Outcome Assessment
Prognosis
Respiratory Distress Syndrome complications
Subjects
Details
- Language :
- English
- ISSN :
- 1466-609X
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Critical care (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 28222804
- Full Text :
- https://doi.org/10.1186/s13054-017-1615-3