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Evaluation of 18-F-fluoro-2-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) as a staging and monitoring tool for dogs with stage-2 splenic hemangiosarcoma - A pilot study.
- Source :
-
PloS one [PLoS One] 2017 Feb 21; Vol. 12 (2), pp. e0172651. Date of Electronic Publication: 2017 Feb 21 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Positron Emission Tomography-Computed Tomography (PET-CT) is routinely used for staging and monitoring of human cancer patients and is becoming increasingly available in veterinary medicine. In this study, 18-fluorodeoxyglucose (18FDG)-PET-CT was used in dogs with naturally occurring splenic hemangiosarcoma (HSA) to assess its utility as a staging and monitoring modality as compared to standard radiography and ultrasonography. Nine dogs with stage-2 HSA underwent 18FDG-PET-CT following splenectomy and prior to commencement of chemotherapy. Routine staging (thoracic radiography and abdominal ultrasonography) was performed prior to 18FDG-PET-CT in all dogs. When abnormalities not identified on routine tests were noted on 18FDG-PET-CT, owners were given the option to repeat a PET-CT following treatment with eBAT. A PET-CT scan was repeated on Day 21 in three dogs. Abnormalities not observed on conventional staging tools, and most consistent with malignant disease based on location, appearance, and outcome, were detected in two dogs and included a right atrial mass and a hepatic nodule, respectively. These lesions were larger and had higher metabolic activity on the second scans. 18FDG-PET-CT has potential to provide important prognostic information and influence treatment recommendations for dogs with stage-2 HSA. Additional studies will be needed to precisely define the value of this imaging tool for staging and therapy monitoring in dogs with this and other cancers.
- Subjects :
- Animals
Dog Diseases surgery
Dogs
Female
Heart Neoplasms diagnostic imaging
Heart Neoplasms secondary
Heart Neoplasms veterinary
Hemangiosarcoma secondary
Hemangiosarcoma surgery
Liver Neoplasms diagnostic imaging
Liver Neoplasms secondary
Liver Neoplasms veterinary
Male
Neoplasm Staging methods
Pilot Projects
Prognosis
Radiography, Thoracic
Splenectomy
Splenic Neoplasms surgery
Ultrasonography
Dog Diseases diagnostic imaging
Fluorodeoxyglucose F18
Hemangiosarcoma diagnostic imaging
Hemangiosarcoma veterinary
Neoplasm Staging veterinary
Positron Emission Tomography Computed Tomography veterinary
Radiopharmaceuticals
Splenic Neoplasms diagnostic imaging
Splenic Neoplasms veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 28222142
- Full Text :
- https://doi.org/10.1371/journal.pone.0172651