Back to Search
Start Over
Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring.
- Source :
-
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2017 May; Vol. 58, pp. 74-81. Date of Electronic Publication: 2017 Feb 20. - Publication Year :
- 2017
-
Abstract
- Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam's maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500mg/kg/day, were offered to lactating mothers up to PND9. Thereafter, all mice were provided regular drinking water. On PND2, all litters were culled to 8 pups (4 males and 4 females). Maternal behavior was evaluated at PND3, 6, 9, and 12, and at PND7 we evaluated locomotor activity in the open field. Reflex parameters and physical development of offspring were evaluated during lactation. At PND7, analysis of ultrasonic vocalization (USV) was performed. When the animals reached adolescence, we evaluated their performance in the open field, elevated plus maze (EPM), and marble burying. Our data demonstrated that maternal dipyrone treatment during lactation not only altered maternal behavior and the onset of physical and neurodevelopmental landmarks but also had an impact on anxiety-like behavior in offspring.<br /> (Copyright © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Age Factors
Animals
Animals, Newborn
Developmental Disabilities etiology
Dose-Response Relationship, Drug
Drinking Behavior drug effects
Exploratory Behavior drug effects
Female
Humans
Lactation drug effects
Male
Maze Learning drug effects
Mice
Pregnancy
Vocalization, Animal drug effects
Anti-Inflammatory Agents, Non-Steroidal toxicity
Anxiety chemically induced
Dipyrone toxicity
Maternal Behavior drug effects
Prenatal Exposure Delayed Effects chemically induced
Prenatal Exposure Delayed Effects physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-474X
- Volume :
- 58
- Database :
- MEDLINE
- Journal :
- International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 28219765
- Full Text :
- https://doi.org/10.1016/j.ijdevneu.2017.02.005