Outbreak of dengue virus type-3 in Malakand, Pakistan 2015; A laboratory perspective.

Authors :: Suleman M
Faryal R
Alam MM
Khurshid A
Sharif S
Shaukat S
Angez M
Umair M
Sufian MM
Arshad Y
Inam T
Zaidi SSZ
Source :: Acta tropica [Acta Trop] 2017 May; Vol. 169, pp. 202-206. Date of Electronic Publication: 2017 Feb 17.
Publication Year :: 2017
Abstract: An outbreak of dengue fever was reported in Malakand district, Khyber Pakhtunkhwa (KP) province of Pakistan during 2015. Detection of viral RNA by real-time PCR confirmed dengue virus serotype-3 (DENV-3) to be the causative agent causing the outbreak. Phylogenetic analysis based on partial E-NS1 gene sequences showed that the DENV-3 viruses belonged to genotype III with maximum homology with the dengue-3 strains previously reported from Pakistan and India. Our current report provides updated information on molecular epidemiology and phylogenetic analysis of dengue virus serotypes responsible for 2015 outbreak in KP.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)

Subjects :: Genotype
Humans
India epidemiology
Laboratories
Molecular Epidemiology
Pakistan epidemiology
Phylogeny
RNA, Viral genetics
Real-Time Polymerase Chain Reaction
Serogroup
Dengue epidemiology
Dengue Virus classification
Disease Outbreaks

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