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5-Amino-1-(2',3'- O -iso-propyl-idene-d-ribit-yl)-1 H -imidazole-4-carboxamide: a crystal structure with Z ' = 4.

5-Amino-1-(2',3'- O -iso-propyl-idene-d-ribit-yl)-1 H -imidazole-4-carboxamide: a crystal structure with Z ' = 4.

Authors :
Piccialli V
Borbone N
Oliviero G
Piccialli G
D'Errico S
Centore R
Source :
Acta crystallographica. Section E, Crystallographic communications [Acta Crystallogr E Crystallogr Commun] 2017 Jan 13; Vol. 73 (Pt 2), pp. 183-187. Date of Electronic Publication: 2017 Jan 13 (Print Publication: 2017).
Publication Year :
2017

Abstract

The title compound, C <subscript>12</subscript> H <subscript>20</subscript> N <subscript>4</subscript> O <subscript>5</subscript> , crystallizes in the monoclinic space group P 2 <subscript>1</subscript> , with four crystallographically independent mol-ecules in the asymmetric unit. The four mol-ecules have a very similar conformation that is basically determined by the formation of two intra-molecular hydrogen bonds between the amino NH <subscript>2</subscript> donors and the carbonyl and ring O-atom acceptors, forming, respectively, R (6) and R (7) ring motifs.. In the crystal, inter-molecular hydrogen bonding leads to the formation of R <subscript>2</subscript> <superscript>2</superscript> (10) ring patterns, involving one amide CONH <subscript>2</subscript> donor and an imidazole N-atom acceptor. The cluster of the four independent mol-ecules has approximate non-crystallographic C <subscript>2</subscript> point symmetry. The structural analysis also shows that during the synthesis of the title compound, the reductive cleavage of the d-ribose ring of the inosine precursor proceeds stereoselectively, with retention of configuration.

Details

Language :
English
ISSN :
2056-9890
Volume :
73
Issue :
Pt 2
Database :
MEDLINE
Journal :
Acta crystallographica. Section E, Crystallographic communications
Publication Type :
Academic Journal
Accession number :
28217338
Full Text :
https://doi.org/10.1107/S2056989017000500