Study of poly-ɛ-caprolactone membranes for pleurodesis.

Authors :: Chen KC
Hsieh MS
Li YR
Lin YC
Lai HS
Shieh MJ
Chen JS
Young TH
Source :: Journal of the Formosan Medical Association = Taiwan yi zhi [J Formos Med Assoc] 2017 Nov; Vol. 116 (11), pp. 880-887. Date of Electronic Publication: 2017 Feb 16.
Publication Year :: 2017
Abstract: Background/purpose: Pleurodesis with biomaterial membrane is an emerging treatment method for pneumothorax. However, the ideal one for the common disease is still under debate.<br />Methods: We investigate the Poly-ε-caprolactone (PCL) membrane pleurodesis by using New Zealand White rabbits, which was sacrificed for examination one month later. Moreover, inflammation and fibrosis scoring were done under microscopic evaluation, as well as Western blot analysis in vitro and in vivo.<br />Results: Gross evaluation of pleurodesis score revealed that dense PCL membrane produced moderate pleural adhesion, while porous PCL membrane exhibited significantly higher pleurodesis scores.<br />Conclusion: PCL membrane induced significant degree of adhesion, both within the abdomen and chest of the rabbits. The porous PCL membrane produces more intensive adhesion than dense one. Fibronectin plays an important role in the process of pleurodesis. Further study is required for the clinical application of the promising material.<br /> (Copyright © 2017. Published by Elsevier B.V.)