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Impact of Renal Disease on Patients with Hepatitis C: A Retrospective Analysis of Disease Burden, Clinical Outcomes, and Health Care Utilization and Cost.
- Source :
-
Nephron [Nephron] 2017; Vol. 136 (2), pp. 54-61. Date of Electronic Publication: 2017 Feb 18. - Publication Year :
- 2017
-
Abstract
- Background/aims: Few studies explore the magnitude of the disease burden and health care utilization imposed by renal disease among patients with hepatitis C virus (HCV). We aimed to describe the characteristics, outcomes, and health care utilization and costs of patients with HCV with and without renal impairment.<br />Methods: This retrospective analysis used 2 administrative claims databases: the US commercially insured population in Truven Health MarketScan® data (aged 20-64 years), and the US Medicare fee-for-service population in the Medicare 20% sample (aged ≥65 years). Baseline characteristics and comorbid conditions were identified from claims during 2011; patients were followed for up to 1 year (beginning January 1, 2012) to identify health outcomes of interest and health care utilization and costs.<br />Results: In the MarketScan and Medicare databases, 35,965 and 10,608 patients with HCV were identified, 8.5 and 26.5% with evidence of renal disease (chronic kidney disease [CKD] or end-stage renal disease [ESRD]). Most comorbid conditions and unadjusted outcome rates increased across groups from patients with no evidence of renal disease to non-ESRD CKD to ESRD. Health care utilization followed a similar pattern, as did the costs.<br />Conclusions: Our findings suggest that HCV patients with concurrent renal disease have significantly more comorbidity, a higher likelihood of negative health outcomes, and higher health care utilization and costs.<br /> (© 2017 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Comorbidity
Cost of Illness
Databases, Factual
Female
Health Care Costs
Hepatitis C economics
Humans
Kidney Diseases economics
Kidney Failure, Chronic complications
Kidney Failure, Chronic therapy
Male
Medicare
Middle Aged
Patient Acceptance of Health Care
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic therapy
Retrospective Studies
Treatment Outcome
United States
Young Adult
Hepatitis C complications
Hepatitis C therapy
Kidney Diseases complications
Kidney Diseases therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2235-3186
- Volume :
- 136
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nephron
- Publication Type :
- Academic Journal
- Accession number :
- 28214902
- Full Text :
- https://doi.org/10.1159/000454684