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IgG-degrading enzyme of Streptococcus pyogenes (IdeS) prevents disease progression and facilitates improvement in a rabbit model of Guillain-Barré syndrome.
- Source :
-
Experimental neurology [Exp Neurol] 2017 May; Vol. 291, pp. 134-140. Date of Electronic Publication: 2017 Feb 16. - Publication Year :
- 2017
-
Abstract
- Autoantibodies binding to peripheral nerves followed by complement deposition and membrane attack complex formation results in nerve damage in Guillain-Barré syndrome (GBS). Strategies to remove the pathogenic autoantibodies or block the complement deposition benefit most patients with GBS. Immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS) is a cysteine protease which cleaves IgG antibodies into F(ab') <subscript>2</subscript> and Fc fragments. In this study, using a rabbit model of axonal GBS, acute motor axonal neuropathy (AMAN), we demonstrated that IdeS treatment significantly reduced the disruption of Nav channels as well as activated C3 deposition at the anterior spinal root nodes of Ranvier in AMAN rabbits. IdeS significantly promoted the clinical recovery of AMAN rabbits and there were significant lower frequencies of axonal degeneration in anterior spinal roots of AMAN rabbits with IdeS treatment compared to the saline controls. Our data support that IdeS treatment is a promising therapeutic strategy for GBS.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Autoantibodies
Complement C3 metabolism
Disease Models, Animal
Disease Progression
Enzyme-Linked Immunosorbent Assay
G(M1) Ganglioside immunology
Guillain-Barre Syndrome immunology
Immunoglobulin G blood
Neural Conduction physiology
Rabbits
Ranvier's Nodes metabolism
Ranvier's Nodes pathology
Sodium Channels metabolism
Statistics, Nonparametric
Time Factors
Bacterial Proteins immunology
Bacterial Proteins therapeutic use
Guillain-Barre Syndrome therapy
Immunoglobulin G therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2430
- Volume :
- 291
- Database :
- MEDLINE
- Journal :
- Experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 28214515
- Full Text :
- https://doi.org/10.1016/j.expneurol.2017.02.010