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Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1.
- Source :
-
Aging [Aging (Albany NY)] 2017 Feb 15; Vol. 9 (2), pp. 315-339. - Publication Year :
- 2017
-
Abstract
- MtDNA mutator mice exhibit marked features of premature aging. We find that these mice treated from age of ≈100 days with the mitochondria-targeted antioxidant SkQ1 showed a delayed appearance of traits of aging such as kyphosis, alopecia, lowering of body temperature, body weight loss, as well as ameliorated heart, kidney and liver pathologies. These effects of SkQ1 are suggested to be related to an alleviation of the effects of an enhanced reactive oxygen species (ROS) level in mtDNA mutator mice: the increased mitochondrial ROS released due to mitochondrial mutations probably interact with polyunsaturated fatty acids in cardiolipin, releasing malondialdehyde and 4-hydroxynonenal that form protein adducts and thus diminishes mitochondrial functions. SkQ1 counteracts this as it scavenges mitochondrial ROS. As the results, the normal mitochondrial ultrastructure is preserved in liver and heart; the phosphorylation capacity of skeletal muscle mitochondria as well as the thermogenic capacity of brown adipose tissue is also improved. The SkQ1-treated mice live significantly longer (335 versus 290 days). These data may be relevant in relation to treatment of mitochondrial diseases particularly and the process of aging in general.
- Subjects :
- Adipose Tissue, Brown drug effects
Adipose Tissue, Brown metabolism
Aging metabolism
Animals
Body Temperature physiology
Body Weight physiology
DNA, Mitochondrial genetics
Heart drug effects
Liver drug effects
Liver metabolism
Longevity physiology
Mice
Mitochondria genetics
Mitochondria metabolism
Muscle, Skeletal drug effects
Muscle, Skeletal metabolism
Myocardium metabolism
Plastoquinone pharmacology
Reactive Oxygen Species metabolism
Aging drug effects
DNA, Mitochondrial metabolism
Longevity drug effects
Mutation
Plastoquinone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1945-4589
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Aging
- Publication Type :
- Academic Journal
- Accession number :
- 28209927
- Full Text :
- https://doi.org/10.18632/aging.101174