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The Therapeutic Potential of Migrastatin-Core Analogs for the Treatment of Metastatic Cancer.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2017 Feb 09; Vol. 22 (2). Date of Electronic Publication: 2017 Feb 09. - Publication Year :
- 2017
-
Abstract
- Tumor metastasis is a complex process in which cells detach from the primary tumor and colonize a distant organ. Metastasis is also the main process responsible for cancer-related death. Despite the enormous efforts made to unravel the metastatic process, there is no effective therapy, and patients with metastatic tumors have poor prognosis. In this regard, there is an urgent need for new therapeutic tools for the treatment of this disease. Small molecules with the capacity to reduce cell migration could be used to treat metastasis. Migrastatin-core analogs are naturally inspired macrocycles that inhibit pathological cell migration and are able to reduce metastasis in animal models. Migrastatin analogs can be synthesized from a common advanced intermediate. Herein we present a review of the synthetic approaches that can be used to prepare this key intermediate, together with a review of the biological activity of migrastatin-core analogs and current hypotheses concerning their mechanism of action.
- Subjects :
- Animals
Antineoplastic Agents chemical synthesis
Antineoplastic Agents therapeutic use
Biological Products chemical synthesis
Biological Products therapeutic use
Cell Line, Tumor
Cell Movement drug effects
Drug Evaluation, Preclinical
Humans
Macrolides chemical synthesis
Macrolides therapeutic use
Neoplasm Metastasis
Neoplasms drug therapy
Neoplasms genetics
Neoplasms metabolism
Neoplasms pathology
Piperidones chemical synthesis
Piperidones therapeutic use
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Biological Products chemistry
Biological Products pharmacology
Macrolides chemistry
Macrolides pharmacology
Piperidones chemistry
Piperidones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 28208778
- Full Text :
- https://doi.org/10.3390/molecules22020198