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Extracellular regulation of BMP signaling: welcome to the matrix.
- Source :
-
Biochemical Society transactions [Biochem Soc Trans] 2017 Feb 08; Vol. 45 (1), pp. 173-181. - Publication Year :
- 2017
-
Abstract
- Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.<br /> (© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.)
Details
- Language :
- English
- ISSN :
- 1470-8752
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical Society transactions
- Publication Type :
- Academic Journal
- Accession number :
- 28202671
- Full Text :
- https://doi.org/10.1042/BST20160263