Clinical Factors Predicting Tumour Upgrading in Patients Under Active Surveillance and Elected to Active Treatment after Disease Reclassification or Progression.

Authors :: Porcaro AB
Cavicchioli F
De Luyk N
Mattevi D
Corsi P
Sebben M
Tafuri A
Processali T
Inverardi D
Cacciamani G
De Marchi D
Balzarro M
Cerruto MA
Brunelli M
Novella G
Siracusano S
Artibani W
Source :: Urologia internationalis [Urol Int] 2017; Vol. 99 (2), pp. 186-193. Date of Electronic Publication: 2017 Feb 14.
Publication Year :: 2017
Abstract: Objectives: To evaluate clinical factors associated with tumour upgrading (UPG) in low-intermediate risk patients who progressed while under active surveillance (AS) and underwent delayed radical prostatectomy.<br />Material and Methods: The evaluated factors included prostate specific antigen (PSA), prostate volume, PSA density and number of biopsy positive cores (BPC). Multivariate logistic regression by the forward step Wald procedure was used.<br />Results: The study evaluated 24 patients who had UPG in 13 cases (54.2%). Independent factors associated with tumour UPG included PSA (OR 2.1; p = 0.047) and BPC (OR 2; p = 0.042).<br />Conclusions: Clinical factors associated with UPG were identified in patients who were under AS for with low-intermediate risk disease. Preoperative PSA levels and number of BPC were independent factors associated with UPG in a contemporary cohort of patients who progressed under AS and underwent delayed active treatment.<br /> (© 2017 S. Karger AG, Basel.)

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