Back to Search
Start Over
Interleukin-1 receptor antagonist, a biomarker of response to anti-TB treatment in HIV/TB co-infected patients.
- Source :
-
The Journal of infection [J Infect] 2017 May; Vol. 74 (5), pp. 456-465. Date of Electronic Publication: 2017 Feb 09. - Publication Year :
- 2017
-
Abstract
- Objectives: Despite the high frequency of tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in human immunodeficiency virus (HIV)/TB co-infected patients, no diagnostic test is available. Here, we investigated whether monocyte/macrophage activation markers can predict TB-IRIS occurrence and if they are modulated by anti-TB treatment.<br />Methods: Frozen plasma was obtained from 127 HIV/TB co-infected adults naïve for antiretroviral therapy, enrolled in the CAMELIA trial, 36 of whom developed TB-IRIS. Concentrations of IL-1Ra, sCD14, and sCD163 were measured at anti-TB treatment onset (baseline), after 8 weeks of anti-TB treatment and at TB-IRIS time.<br />Results: At baseline, IL-1Ra and sCD14 concentrations were similar in TB-IRIS and non-IRIS patients. sCD163 concentrations, although significantly higher in TB-IRIS patients, did not remain associated with TB-IRIS occurrence in multivariate analysis. At the time of TB-IRIS, patients displayed higher concentrations of IL-1Ra (p = 0.002) and sCD14 (p < 0.001). The most striking result was the significant decrease in IL-1Ra after 8 weeks of anti-TB treatment (median reduction: -63% (p < 0.0001)).<br />Conclusions: None of the biomarkers tested was associated with TB-IRIS occurrence. However, repeated measurement of IL-1Ra could help for the diagnosis of TB-IRIS. The substantial reduction of IL-1Ra under treatment suggests that IL-1Ra could be a surrogate biomarker of anti-TB treatment response in HIV-infected patients.<br /> (Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Case-Control Studies
Female
Humans
Male
Randomized Controlled Trials as Topic
Antitubercular Agents therapeutic use
Biomarkers blood
HIV Infections complications
Immune Reconstitution Inflammatory Syndrome blood
Immune Reconstitution Inflammatory Syndrome complications
Immune Reconstitution Inflammatory Syndrome diagnosis
Interleukin 1 Receptor Antagonist Protein blood
Tuberculosis blood
Tuberculosis complications
Tuberculosis diagnosis
Tuberculosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2742
- Volume :
- 74
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infection
- Publication Type :
- Academic Journal
- Accession number :
- 28189712
- Full Text :
- https://doi.org/10.1016/j.jinf.2017.01.016