Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta).

Authors :: Goldschmidt B
Calado MI
Resende FC
Caldas RM
Pinto LW
Lopes CA
França FG
Meireles BS
Souza IV
Source :: Journal of medical primatology [J Med Primatol] 2017 Apr; Vol. 46 (2), pp. 51-55. Date of Electronic Publication: 2017 Feb 10.
Publication Year :: 2017
Abstract: Osteosarcoma (OS) is the most common type of bone cancer, especially in young. Telangiectatic osteosarcoma (TO) is a rare variant of OS, and hence, its occurrence, presentation, and prognosis are poorly understood. A 4-year-old female rhesus monkey presenting lameness and swelling was examined for a mass on the right humerus. Radiography revealed fracture and disorganized structure of bone tissue. Histopathological examination revealed malignant neoplasm composed of anaplastic osteoblasts, which invaded the bone marrow and surrounded blood-filled cysts in the epiphysis and diaphysis forming septa. Cytogenetic analysis showed aneuploid cells, supernumerary AgNORs, and a marker fragment. The neoplasm was diagnosed as TO. To our knowledge, the occurrence of TO and its cytogenetic analysis were reported for the first time in non-human primates.<br /> (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)