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Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2017 Feb 21; Vol. 53 (16), pp. 2451-2454. - Publication Year :
- 2017
-
Abstract
- Nanoscale chemical mapping of newly-synthesised phospholipid molecules inside a mammalian cell is demonstrated using tip-enhanced Raman spectroscopy (TERS) for the first time using mouse pre-adipocyte cells as a model system. Newly-synthesised membrane phospholipid distribution within a pre-adipocyte cell is mapped with <20 nm spatial resolution, overcoming the diffraction limit of confocal Raman spectroscopy via plasmonic enhancement of Raman signals at a TERS tip-apex.
- Subjects :
- Adipocytes chemistry
Animals
Deuterium
Intracellular Membranes chemistry
Mice
Phosphatidylcholines chemistry
Phosphatidylcholines metabolism
Phospholipids biosynthesis
Phospholipids chemistry
Spectrum Analysis, Raman methods
Adipocytes ultrastructure
Intracellular Membranes ultrastructure
Phospholipids metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 53
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 28177338
- Full Text :
- https://doi.org/10.1039/c6cc10226c