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Reconsolidation-induced rescue of a remote fear memory blocked by an early cortical inhibition: Involvement of the anterior cingulate cortex and the mediation by the thalamic nucleus reuniens.
- Source :
-
Hippocampus [Hippocampus] 2017 May; Vol. 27 (5), pp. 596-607. Date of Electronic Publication: 2017 Mar 07. - Publication Year :
- 2017
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Abstract
- Systems consolidation is a time-dependent reorganization process involving neocortical and hippocampal networks underlying memory storage and retrieval. The involvement of the hippocampus during acquisition is well described; however we know much less about the concomitant contribution of cortical activity levels to the formation of stable remote memories. Here, after a reversible pharmacological inhibition of the anterior cingulate cortex (ACC) during the acquisition of a contextual fear conditioning, retrieval of both recent and remote memories were impaired, an effect that was reverted by a single memory reactivation session 48 h after training, through a destabilization-dependent mechanism interpreted as reconsolidation, that restored the normal course of systems consolidation in order to rescue a remote memory. Next we have shown that the integrity of both the anterior cingulate cortex and the thalamic nucleus reuniens (RE) were required for this reactivation-induced memory rescue. Because lidocaine infused into the RE inhibited LTP induction in the CA1-anterior cingulate cortex pathways, it seems that RE is a necessary component of the circuit underlying systems consolidation, mediating communication between dorsal hippocampus and cortical areas. To our notice, this is the first demonstration of the rescue of remote memories disrupted by ACC inhibition during acquisition, via a reconsolidation-driven mechanism. We have also shown the importance of RE to ensure the interconnection among brain areas that collectively seem to control the natural course of systems consolidation and allow the persistence of relevant emotional engrams. © 2017 Wiley Periodicals, Inc.<br /> (© 2017 Wiley Periodicals, Inc.)
- Subjects :
- Animals
CA1 Region, Hippocampal drug effects
CA1 Region, Hippocampal physiology
Calcium Channel Blockers pharmacology
Conditioning, Psychological drug effects
Excitatory Postsynaptic Potentials drug effects
Excitatory Postsynaptic Potentials physiology
Fear drug effects
GABA-A Receptor Agonists pharmacology
Gyrus Cinguli drug effects
Lidocaine pharmacology
Long-Term Potentiation drug effects
Long-Term Potentiation physiology
Male
Memory Consolidation drug effects
Memory, Short-Term drug effects
Memory, Short-Term physiology
Muscimol pharmacology
Neural Pathways drug effects
Neural Pathways physiology
Nimodipine pharmacology
Rats, Wistar
Voltage-Gated Sodium Channel Blockers pharmacology
Conditioning, Psychological physiology
Fear physiology
Gyrus Cinguli physiology
Memory Consolidation physiology
Midline Thalamic Nuclei physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-1063
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Hippocampus
- Publication Type :
- Academic Journal
- Accession number :
- 28176459
- Full Text :
- https://doi.org/10.1002/hipo.22715