Role of simeprevir plasma concentrations in HCV treated patients with dermatological manifestations.

Authors :: Boglione L
De Nicolò A
Mornese Pinna S
Cusato J
Favata F
Ariaudo A
Carcieri C
Cariti G
Di Perri G
D'Avolio A
Source :: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2017 Jun; Vol. 49 (6), pp. 705-708. Date of Electronic Publication: 2017 Jan 17.
Publication Year :: 2017
Abstract: Background and Aims: Up till now the role of simeprevir plasma concentrations has not been described in treated patients affected by chronic hepatitis C and with dermatological side-effects. In this study, we have evaluated a possible relationship between plasma levels and the onset of skin complaints for the first time.<br />Methods: We report a clinical and pharmacokinetic analysis of 56 patients treated with simeprevir-based therapies.<br />Results: Simeprevir plasma concentrations were significantly related to dermatological side-effects at early time-points (P<0.001). In logistic regression, simeprevir concentrations at 1 week was the best predictive factor forskin symptoms (OR=1.901, 95%IC: 1.001-2.304; P=0.007).<br />Conclusion: Simeprevir plasma measurements could be a useful tool in a real-life clinical setting for prevention of dermatological symptoms.<br /> (Copyright © 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)

Language :: English
ISSN :: 1878-3562
Volume :: 49
Issue :: 6
Database :: MEDLINE
Journal :: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Publication Type :: Academic Journal
Accession number :: 28174003
Full Text :: https://doi.org/10.1016/j.dld.2017.01.144

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