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Comparison of pro-inflammatory cytokines of non-healing and healing cutaneous leishmaniasis.
- Source :
-
Scandinavian journal of immunology [Scand J Immunol] 2017 Apr; Vol. 85 (4), pp. 291-299. - Publication Year :
- 2017
-
Abstract
- Cutaneous leishmaniasis (CL) heals spontaneously within several weeks or months, but, in rare cases, CL-active lesions last for many years. In this study, we assessed cell-mediated immunity in non-healing CL through the measurement of three pro-inflammatory cytokines: Interferon-γ (IFN-γ), IL-17a and CXCL-11. For this, 32 patients afflicted with healing or non-healing CL were recruited in this study. Peripheral blood mononuclear cells (PBMCs) of every patient were treated with three antigens: purified protein derivative (PPD), soluble Leishmania antigen (SLA) and phytohaemagglutinin (PHA). Cytokine quantification was performed using enzyme-linked immunosorbent assay (ELISA) method. Results of our study showed that neither cytokine produced in the presence of a PPD stimulator (as an irrelevant antigen) significantly differed between the healing and non-healing groups (P-value ≥0.05 for all of them). However, IFN-γ, CXCL-11 and IL-17a levels produced in the presence of PHA or SLA were significantly higher within the healing than in the non-healing group (P-value <0.01 for all of them). It seems that appropriate levels of IFN-γ, as well as IL-17a and CXCL-11, contribute to the control of Leishmania infection.<br /> (© 2017 The Foundation for the Scandinavian Journal of Immunology.)
- Subjects :
- Adolescent
Adult
Antigens, Protozoan immunology
Child
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Leishmaniasis, Cutaneous parasitology
Male
Middle Aged
Phytohemagglutinins immunology
Tuberculin immunology
Young Adult
Chemokine CXCL11 blood
Interferon-gamma blood
Interleukin-17 blood
Leishmania immunology
Leishmaniasis, Cutaneous blood
Leishmaniasis, Cutaneous immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-3083
- Volume :
- 85
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 28168727
- Full Text :
- https://doi.org/10.1111/sji.12534