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Assessment of the Anterior Chamber Flare and Macular Thickness in Patients Treated with Topical Antiglaucomatous Drugs.
- Source :
-
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics [J Ocul Pharmacol Ther] 2017 Apr; Vol. 33 (3), pp. 170-175. Date of Electronic Publication: 2017 Feb 06. - Publication Year :
- 2017
-
Abstract
- Purpose: To determine the changes in the anterior chamber flare and central macular thickness (CMT) under topical antiglaucomatous therapy.<br />Methods: This study included 121 eyes of 73 patients and 36 eyes of 18 controls. Glaucoma patients were divided into 3 groups (timolol maleate, latanoprost, and bimatoprost). Control eyes did not receive any medications. Flare and CMT measurements were performed at baseline and follow-up visits (15th day, and 1st, 3rd, 6th, and 12th month).<br />Results: Statistically significant increases were detected in the flare values in the bimatoprost and latanoprost groups (P < 0.001, P = 0.011, respectively). Significant increases were also found in CMT values measured in these 2 groups (P < 0.001, P = 0.002, respectively). However, increased flare and CMT values were not clinically manifested as uveitis and macular edema. Flare and CMT values did not change statistically in the timolol maleate and control groups.<br />Conclusions: Although the use of prostaglandin (PG) analogs was found to be associated with increased flare and CMT, these increases were not clinically significant. PG analog monotherapy may be safely and effectively used in the treatment of glaucoma.
- Subjects :
- Administration, Topical
Anterior Chamber pathology
Antihypertensive Agents administration & dosage
Bimatoprost administration & dosage
Female
Glaucoma diagnosis
Glaucoma drug therapy
Humans
Latanoprost
Macular Degeneration metabolism
Macular Degeneration pathology
Male
Middle Aged
Prostaglandins F, Synthetic administration & dosage
Timolol administration & dosage
Anterior Chamber drug effects
Antihypertensive Agents pharmacology
Bimatoprost pharmacology
Macular Degeneration drug therapy
Prostaglandins F, Synthetic pharmacology
Timolol pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-7732
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 28165835
- Full Text :
- https://doi.org/10.1089/jop.2016.0128