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Effect of prophylactic topical hypotensive medications in reducing the incidence of postoperative ocular hypertension after phacoemulsification in dogs.
- Source :
-
Veterinary ophthalmology [Vet Ophthalmol] 2017 Nov; Vol. 20 (6), pp. 514-521. Date of Electronic Publication: 2017 Feb 06. - Publication Year :
- 2017
-
Abstract
- Objective: To determine whether topical hypotensive medications prevent postoperative ocular hypertension (POH) after phacoemulsification.<br />Animals Studied: 52 client-owned dogs (88 eyes).<br />Procedures: Diabetic and nondiabetic dogs having undergone phacoemulsification were included in this retrospective study. The control group received no ocular hypotensive medications. The treatment groups received latanoprost, dorzolamide, or dorzolamide/timolol, beginning immediately after surgery, for 2-week duration. IOPs were obtained at initial examination followed by 4 h, 24 h, 7 days, and 14 days postoperatively. POH was defined as an IOP above 20 mmHg (POH20) or 25 mmHg (POH25).<br />Results: POH20 occurred in 33 of 87 eyes (37.93%), including 11 of 21 eyes (52.38%) in the control group, three of 23 eyes (13.04%) in the latanoprost group, eight of 15 eyes (53.33%) in the dorzolamide group, and 11 of 28 eyes (39.29%) in the dorzolamide/timolol group. Active treatment groups were compared to the control group, and the overall group effect was not significant (P = 0.11). POH25 occurred in 22 of 86 eyes (25.58%), including seven of 21 eyes (33.33%) in the control group, two of 23 eyes (8.70%) in the latanoprost group, five of 15 eyes (33.33%) in the dorzolamide group, and eight of 27 eyes (29.63%) in the dorzolamide/timolol group. Active treatment groups were compared to the control group, and the overall group effect was not significant (P = 0.31). Intraoperative use of intracameral tissue plasminogen activator significantly decreased the chances of POH25 (P = 0.0063).<br />Conclusions and Clinical Relevance: The latanoprost group had a substantially lower percentage of POH 20 and POH25 compared to the control and other active treatment groups, although statistical significance was not achieved. Intraoperative intracameral tissue plasminogen activator decreased the incidence of POH25.<br /> (© 2017 American College of Veterinary Ophthalmologists.)
- Subjects :
- Administration, Topical
Animals
Dog Diseases epidemiology
Dog Diseases etiology
Dogs
Female
Incidence
Intraocular Pressure drug effects
Latanoprost
Male
Ocular Hypertension epidemiology
Ocular Hypertension etiology
Ocular Hypertension prevention & control
Phacoemulsification adverse effects
Postoperative Complications prevention & control
Pre-Exposure Prophylaxis
Prostaglandins F, Synthetic administration & dosage
Retrospective Studies
Sulfonamides administration & dosage
Thiophenes administration & dosage
Timolol administration & dosage
Dog Diseases prevention & control
Ocular Hypertension veterinary
Ophthalmic Solutions administration & dosage
Phacoemulsification veterinary
Postoperative Complications veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1463-5224
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Veterinary ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 28164422
- Full Text :
- https://doi.org/10.1111/vop.12461