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Low-level environmental metals and metalloids and incident pregnancy loss.
- Source :
-
Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2017 Apr; Vol. 69, pp. 68-74. Date of Electronic Publication: 2017 Feb 02. - Publication Year :
- 2017
-
Abstract
- Environmental exposure to metals and metalloids is associated with pregnancy loss in some but not all studies. We assessed arsenic, cadmium, mercury, and lead concentrations in 501 couples upon trying for pregnancy and followed them throughout pregnancy to estimate the risk of incident pregnancy loss. Using Cox proportional hazard models, we estimated hazard ratios (HR) and 95% confidence intervals (CIs) for pregnancy loss after covariate adjustment for each partner modeled individually then we jointly modeled both partners' concentrations. Incidence of pregnancy loss was 28%. In individual partner models, the highest adjusted HRs were observed for female and male blood cadmium (HR=1.08; CI 0.81, 1.44; HR=1.09; 95% CI 0.84, 1.41, respectively). In couple based models, neither partner's blood cadmium concentrations were associated with loss (HR=1.01; 95% CI 0.75, 1.37; HR=0.92; CI 0.68, 1.25, respectively). We observed no evidence of a significant relation between metal(loids) at these environmentally relevant concentrations and pregnancy loss.<br /> (Published by Elsevier Inc.)
- Subjects :
- Abortion, Spontaneous blood
Adolescent
Adult
Arsenic blood
Cadmium blood
Environmental Exposure analysis
Female
Humans
Lead blood
Male
Maternal Exposure
Mercury blood
Models, Theoretical
Paternal Exposure
Young Adult
Abortion, Spontaneous epidemiology
Environmental Pollutants blood
Pregnancy blood
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1708
- Volume :
- 69
- Database :
- MEDLINE
- Journal :
- Reproductive toxicology (Elmsford, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 28163209
- Full Text :
- https://doi.org/10.1016/j.reprotox.2017.01.011