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Impact of Air Pollution to Genome of Newborns.
- Source :
-
Central European journal of public health [Cent Eur J Public Health] 2016 Dec; Vol. 24 Suppl, pp. S40-S44. - Publication Year :
- 2016
-
Abstract
- The Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM <subscript>2.5</subscript> ) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo[a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity.<br /> (Copyright© by the National Institute of Public Health, Prague 2016.)
- Subjects :
- 8-Hydroxy-2'-Deoxyguanosine
Adult
Benzo(a)pyrene analysis
Czech Republic
DNA Adducts
Deoxyguanosine analogs & derivatives
Deoxyguanosine analysis
Diet
Environmental Monitoring
Female
Humans
Industry
Infant, Newborn
Male
Milk, Human chemistry
Oxidative Stress
Particulate Matter analysis
Pregnancy
Real-Time Polymerase Chain Reaction
Seasons
Air Pollutants analysis
Environmental Exposure analysis
Genome
Polycyclic Aromatic Hydrocarbons analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1210-7778
- Volume :
- 24 Suppl
- Database :
- MEDLINE
- Journal :
- Central European journal of public health
- Publication Type :
- Academic Journal
- Accession number :
- 28160536
- Full Text :
- https://doi.org/10.21101/cejph.a4536