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IgG4-positive cell infiltration in various cardiovascular disorders - results from histopathological analysis of surgical samples.
- Source :
-
BMC cardiovascular disorders [BMC Cardiovasc Disord] 2017 Feb 03; Vol. 17 (1), pp. 52. Date of Electronic Publication: 2017 Feb 03. - Publication Year :
- 2017
-
Abstract
- Background: The diagnosis of Immunoglobulin G4 (IgG4)-related disease (IgG4-RD), in general, depends on serum IgG4 concentrations and histopathological findings; therefore, diagnosis of IgG4-RD in cardiovascular organs/tissues is often difficult owing to the risk of tissue sampling.<br />Methods: Prevalence of IgG4-positive lymphoplasmacytic infiltration in 103 consecutive cardiovascular surgical samples from 98 patients with various cardiovascular diseases was analyzed immunohistochemically.<br />Results: The diagnoses of the enrolled patients included aortic aneurysm (abdominal, n = 8; thoracic, n = 9); aortic dissection (n = 20); aortic stenosis (n = 24), aortic regurgitation (n = 10), and mitral stenosis/regurgitation (n = 17). In total, 10 (9.7%) of the 103 specimens showed IgG4-positive cell infiltration with various intensities; five of these were aortic valve specimens from aortic stenosis, and IgG4-positive cell infiltration was present at >10 /HPF in three of them. In one aortic wall sample from an abdominal aortic aneurysm, various histopathological features of IgG4-RD, such as IgG4-positive cell infiltration, obliterating phlebitis, and storiform fibrosis, were observed.<br />Conclusions: IgG4-positive cell infiltration was observed in 9.7% of the surgical cardiovascular specimens, mainly in the aortic valve from aortic stenosis and in the aortic wall from aortic aneurysm. Whether IgG4-positive cell infiltration has pathophysiological importance in the development or progression of cardiovascular diseases should be investigated in future studies.
- Subjects :
- Aged
Aged, 80 and over
Aorta immunology
Aorta pathology
Aortic Aneurysm immunology
Aortic Aneurysm pathology
Aortic Valve immunology
Aortic Valve pathology
Aortic Valve Stenosis immunology
Aortic Valve Stenosis pathology
Aortography methods
Biomarkers analysis
Biopsy
Cardiovascular Diseases diagnostic imaging
Cardiovascular Diseases pathology
Cardiovascular Diseases surgery
Computed Tomography Angiography
Cross-Sectional Studies
Female
Humans
Immunohistochemistry
Male
Middle Aged
Plasma Cells pathology
Cardiovascular Diseases immunology
Chemotaxis, Leukocyte
Immunoglobulin G analysis
Plasma Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2261
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cardiovascular disorders
- Publication Type :
- Academic Journal
- Accession number :
- 28158996
- Full Text :
- https://doi.org/10.1186/s12872-017-0488-3