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Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma.
- Source :
-
PloS one [PLoS One] 2017 Feb 02; Vol. 12 (2), pp. e0171036. Date of Electronic Publication: 2017 Feb 02 (Print Publication: 2017). - Publication Year :
- 2017
-
Abstract
- Zinc fingers and homeoboxes (ZHX) is a transcription repressor family that contains three members; ZHX1, ZHX2, and ZHX3. Although ZHX family members have been associated with the progression of cancer, their values as prognostic factors in cancer patients have been poorly examined. Renal cell carcinoma (RCC) is a highly heterogeneous, aggressive cancer that responds variably to treatment. Thus, prognostic molecular markers are required to evaluate disease progression and to improve the survival. In clear cell RCC (ccRCC), ZHX1 and ZHX3 expression were found to be down-regulated but ZHX2 was up-regulated, and the expressions of ZHX1 and ZHX3 were significantly associated with pathological stage. Furthermore, Kaplan-Meier and multivariate regression analysis showed that reduction in the mRNA expression of ZHX1 was associated with poorer survival. Taken together, the present study shows loss of ZHX1 is correlated with ccRCC progression and suggests it is an independent prognostic marker in ccRCC.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Aged
Carcinoma, Renal Cell mortality
Carcinoma, Renal Cell pathology
Female
Gene Expression Regulation, Neoplastic
Genes, Homeobox
Humans
Kaplan-Meier Estimate
Kidney Neoplasms mortality
Kidney Neoplasms pathology
Male
Middle Aged
Prognosis
Zinc Fingers
Carcinoma, Renal Cell genetics
Homeodomain Proteins genetics
Kidney Neoplasms genetics
Repressor Proteins genetics
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 28152006
- Full Text :
- https://doi.org/10.1371/journal.pone.0171036