pfk13 -Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.

Authors :: Sutherland CJ
Lansdell P
Sanders M
Muwanguzi J
van Schalkwyk DA
Kaur H
Nolder D
Tucker J
Bennett HM
Otto TD
Berriman M
Patel TA
Lynn R
Gkrania-Klotsas E
Chiodini PL
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Feb 23; Vol. 61 (3). Date of Electronic Publication: 2017 Feb 23 (Print Publication: 2017).
Publication Year :: 2017
Abstract: We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13 -mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.<br /> (Copyright © 2017 Sutherland et al.)

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